4′-DTMP

CAT: 0804-HY-W587663-01Size: 25 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-W587663-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli[1].

CAS Number

21253-58-7

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/4-dtmp.html

Concentration

10mM

Purity

97.85

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=C(OC)C=C(CC2=CN=C(N)N=C2N)C=C1OC

Molecular Formula

C13H16N4O3

Molecular Weight

276.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Cetin E, et al. Kinetic Barrier to Enzyme Inhibition Is Manipulated by Dynamical Local Interactions in E. coli DHFR. J Chem Inf Model. 2023 Aug 14;63 (15) :4839-4849.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Related Products

Catalog	Name
HY-176562	4-DTM-phenoxy-PEG3-CH2COOH
HY-176563	Di (4-morpholine-amide) -4-DTM-phenoxy (3,5-F) -O-PEG3-CH2COOH
HY-W099255-01	Ethyl 4,4,4,4',4',4'-hexafluoro-DL-valinate
HY-W720006	4,4'-Diapo-ω, ω-carotene-4,4'-dial
HY-77910-01	4- (4-Bromophenyl) -4-hydroxypiperidine
HY-W014226	4,4'-Dihydroxybenzophenone
HY-N9038	4',4''-Dihydroxyanigorootin
HY-W011927-01	4,4'-Sulfonyldiphenol
HY-W269747	4,4'-Dimethoxyoctafluorobiphenyl
HY-W011918	4,4'-Dichlorobenzophenone

Alternative Products

Catalog	Name
T78238-01	4′-DTMP
MBS5819905	4'-DTMP
dNMP014-1K	DTMP Disodium Salt
464508	dTMP sodium salt
388461	DTMP Kinase discontinued
C10468-01	dTMP Kinase Antibody
dNMP004-10	DTMP 100mM Sodium Solution
UB-GEN-3744	dTMP Kinase Polyclonal Antibody
FY-AB53069-01	Anti-Deoxythymidine Monophosphate (DTMP)
ES2205-01	DTMP Kinase rabbit pAb

4′-DTMP

Related Products

Alternative Products

Popular Products