(E/Z)-IT-603
CAT:
804-HY-121508-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
(E/Z)-IT-603
- CAS Number: 292168-90-2
- UNSPSC Description: (E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases[1].
- Target Antigen: NF-κB
- Type: Reference compound
- Related Pathways: NF-κB
- Field of Research: Cancer; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/e-z-it-603.html
- Purity: 99.91
- Solubility: DMSO : 125 mg/mL (ultrasonic)
- Smiles: O=C(/C(N1)=C\C2=CC(Br)=CC(OC)=C2O)NC1=S
- Molecular Weight: 329.17
- References & Citations: [1]Yusuke Shono, et al. A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity. Cancer Discov. 2014 May; 4(5): 578-591.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported