SR10221

CAT: 0804-HY-150308-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-150308-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines[1].

CAS Number

1415321-64-0

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sr10221.html

Purity

98.96

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

C[C@@H](C1=CC=C(C=C1)C(C)(C)C)NC(C2=CC=C(C(C(C)=C3C)=C2)N3CC4=CC(O[C@@H](C)C(O)=O)=C(C=C4)Cl)=O

Molecular Formula

C33H37ClN2O4

Molecular Weight

561.11

References & Citations

[1]Sean Irwin, et al. Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists. J Biol Chem. 2022 Nov;298 (11) :102539.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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