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S-Bioallethrin

CAT: 0804-HY-122376-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122376-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
S-Bioallethrin (D-Trans-Allethrin) is a pyrethroid insecticide. S-Bioallethrin disrupts nerve function by modifying the gating kinetics of transitions between the conducting and nonconducting states of voltage-gated sodium channels. S-Bioallethrin also causes inhibition of lymphocyte proliferation and induces histamine release from human basophils[1][2][3][4].
CAS Number
28434-00-6
Product Name Alternative
D-Trans-Allethrin; Esbiol
UNSPSC
12352211
Hazard Statement
H302, H332, H410
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-bioallethrin.html
Purity
98.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C/C(C)=C\[C@@H]1[C@H](C1(C)C)C(O[C@@H]2C(C)=C(C(C2)=O)CC=C)=O
Molecular Formula
C19H26O3
Molecular Weight
302.41
Precautions
H302, H332, H410
References & Citations
[1]McCavera SJ, et al. Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin. Neurotoxicology. 2012;33 (3) :384-390.|[2]Diel F, et al. In vitro effects of the pyrethroid S-bioallethrin on lymphocytes and basophils from atopic and nonatopic subjects. Allergy. 1998 Nov;53 (11) :1052-9. |[3]Tan J, et al. Divergent actions of the pyrethroid insecticides S-bioallethrin, tefluthrin, and deltamethrin on rat Na (v) 1.6 sodium channels. Toxicol Appl Pharmacol. 2010 Sep 15;247 (3) :229-37.|[4]Ray DE, Burr SA, Lister T. The effects of combined exposure to the pyrethroids deltamethrin and S-bioallethrin on hippocampal inhibition and skeletal muscle hyperexcitability in rats. Toxicol Appl Pharmacol. 2006 Oct 15;216 (2) :354-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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