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CTTHWGFTLC, CYCLIC (TFA)

CAT: 0804-HY-P1789A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1789A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM[1].
UNSPSC
12352209
Target
MMP
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ctthwgftlc-cyclic-tfa.html
Purity
98.91
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(N[C@H]1CC2=CNC3=CC=CC=C23)[C@H](CC4=CN=CN4)NC([C@]([H])([C@@H](C)O)NC([C@]([H])([C@@H](C)O)NC([C@@H](N)CSSC[C@@H](C(O)=O)NC([C@H](CC(C)C)NC([C@]([H])([C@@H](C)O)NC([C@H](CC5=CC=CC=C5)NC(CNC1=O)=O)=O)=O)=O)=O)=O)=O.O=C(C(F)(F)F)O
Molecular Formula
C54H72F3N13O16S2
Molecular Weight
1280.35
References & Citations
[1]Medina OP, et al. Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro. Cancer Res. 2001 May 15;61 (10) :3978-85.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MMP-2; MMP-9

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