STAMBP-IN-1

CAT:

804-HY-141852-05

Size:

25 mg

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CAS Number: 896683-78-6
UNSPSC Description: STAMBP-IN-1 is a small-molecule inhibitor of STAMBP deubiquitinase, and interrupts STAMBP-Ub-NALP7 interaction. STAMBP-IN-1 decreases protein level of its inflammasome substrate NALP7 and suppresses IL-1b release after Toll-like receptor (TLR) agonism. STAMBP-IN-1 inhibits the activity of STAMBP to cleave recombinant di-Ub with an IC50 value of 0.33 mM[1].
Target Antigen: Deubiquitinase
Type: Reference compound
Related Pathways: Cell Cycle/DNA Damage
Applications: COVID-19-anti-virus
Field of Research: Inflammation/Immunology
Assay Protocol: https://www.medchemexpress.com/stambp-in-1.html
Solubility: DMSO : 3.29 mg/mL (warming;heat to 80°C)
Smiles: O=C(NCC1=CC=CO1)CSC(N2CCC3=CC=CC=C3)=NC4=C(C=C(N5CCOCC5)C=C4)C2=O
Molecular Weight: 504.60
References & Citations: [1]Bednash JS,et al. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. Nat Commun. 2017 May 11;8:15203.
Shipping Conditions: Room Temperature
Clinical Information: No Development Reported

Cat	Name
HY-141852-03	STAMBP-IN-1
HY-141852-01	STAMBP-IN-1
HY-141852-05	STAMBP-IN-1
HY-141852-04	STAMBP-IN-1
HY-141852-02	STAMBP-IN-1
HY-RS13871	STAMBP Human Pre-designed siRNA Set A
HY-152092-02	MMP-1-IN-1
HY-152092-01	MMP-1-IN-1
HY-151891-06	TASK-1-IN-1
HY-151891-05	TASK-1-IN-1