TASK-1-IN-1

TASK-1-IN-1

• CAS Number: 600125-11-9
• UNSPSC Description: TASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel) inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a reduced inhibition of TASK-3 channels (IC50 of 1750 nM) and not a significant effect on other K+ channels. TASK-1-IN-1 has anticancer effects.
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/task-1-in-1.html
• Solubility: DMSO : 66.67 mg/mL (ultrasonic)
• Smiles: CCC1=CC=CC=C1NC(C2=CC=CC(NC(C3=CC=CC=C3)=O)=C2)=O
• Molecular Weight: 344.41
• References & Citations: [1]Bárbara Arévalo, et al. Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. J Med Chem. 2022 Nov 24;65(22):15014-15027.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported