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Ulodesine

CAT: 0804-HY-19480-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-19480-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ulodesine is a purine nucleoside phosphorylase (PNP) inhibitor. Ulodesine inhibits PNP with IC50 value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia[1][2].
CAS Number
548486-59-5
Product Name Alternative
BCX4208
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ulodesine.html
Purity
99.32
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(NC=C2CN3C[C@H](O)[C@@H](CO)C3)=C2NC=N1
Molecular Formula
C12H16N4O3
Molecular Weight
264.28
References & Citations
[1]Xujuan YANG, et al. Establishment of a novel hyperuricemiaanimal model using mice and assessment ofhyporuricemia action of PNP inhibitor Ulodesine. |[2]Cesar Diaz-Torné, et al. New medications in development for the treatment of hyperuricemia of gout. Curr Opin Rheumatol. 2015 Mar;27 (2) :164-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Chemical Information

Ulodesine

Ulodesine has been used in trials studying the treatment of Gout, Arthritis, Hyperuricemia, and Joint Disease.

CAS Number548486-59-5
PubChem CID135449518
IUPAC Name7-[[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
Molecular FormulaC12H16N4O3
Molecular Weight264.28
XLogP-1.1
Topological Polar Surface Area101
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count19
Formal Charge0
Complexity389
SMILES
C1[C@@H]([C@H](CN1CC2=CNC3=C2N=CNC3=O)O)CO
InChI
InChI=1S/C12H16N4O3/c17-5-8-3-16(4-9(8)18)2-7-1-13-11-10(7)14-6-15-12(11)19/h1,6,8-9,13,17-18H,2-5H2,(H,14,15,19)/t8-,9+/m1/s1
InChIKey
AFNHHLILYQEHKK-BDAKNGLRSA-N
Chemical Structure
2D Structure
2D structure of Ulodesine
CAS: 548486-59-5
CID: 135449518
Formula: C12H16N4O3
MW: 264.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight264.28
XLogP3-1.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass264.12224039
Monoisotopic Mass264.12224039
Topological Polar Surface Area101 Ų
Heavy Atom Count19
Formal Charge0
Complexity389
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5810403Ulodesine
T202983-01Ulodesine succinate anhydrous

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