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Forsythoside B

CAT: 0804-HY-N0029-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0029-01Size:1 mg
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Description
Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.
CAS Number
81525-13-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NF-κB; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Forsythoside_B.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=C(O)C=C(/C=C/C(O[C@H]2[C@H](O[C@]3([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@H](O)[C@H](OCCC4=CC=C(O)C(O)=C4)O[C@@H]2CO[C@H]5[C@H](O)[C@](CO)(O)CO5)=O)C=C1
Molecular Formula
C34H44O19
Molecular Weight
756.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Jiang WL, et al. Forsythoside B protects against experimental sepsis by modulating inflammatory factors. Phytother Res. 2012 Jul;26 (7) :981-7.|[2]Jiang WL, et al. Neuroprotective efficacy and therapeutic window of Forsythoside B: in a rat model of cerebral ischemia and reperfusion injury. Eur J Pharmacol. 2010 Aug 25;640 (1-3) :75-81.|[3]Jiang WL, et al. Cardioprotection with forsythoside B in rat myocardial ischemia-reperfusion injury: relation to inflammation response. Phytomedicine. 2010 Jul;17 (8-9) :635-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NF-κB; TNFRSF5/CD40

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