AT-56

CAT: 0804-HY-13988-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13988-01Size:5 mg
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Description
AT-56 is a potent, selective and orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS), with an IC50 of 95 μM and Ki of 75 μM. AT-56 could selectively suppress the drowsiness or pain reaction mediated by L-PGDS-catalyzed PGD2[1].
CAS Number
[162640-98-4]
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/at-56.html
Purity
99.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N1(CCCCC2=NNN=N2)CC/C(CC1)=C3C4=CC=CC=C4C=CC5=CC=CC=C/35
Molecular Formula
C25H27N5
Molecular Weight
397.52
Precautions
H228, H315, H319
References & Citations
[1]Irikura D, et, al. Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. J Biol Chem. 2009 Mar 20; 284 (12) : 7623-30.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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