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Difluprednate

CAT: 0804-HY-17569-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17569-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Difluprednate is a glucocorticoid receptor (GC receptor) agonist with a Ki of 0.78 nM. Difluprednate's active metabolite 21-deacetylated difluprednate (DFB) is a competitive agonist of GC receptors with a Ki of 0.061 nM. Difluprednate binds to GC receptors through metabolism to DFB, regulating the transcription of inflammatory mediator genes, thereby exerting anti-inflammatory activity. Difluprednate can be used for research related to ocular inflammation, such as postoperative inflammation, anterior uveitis, etc[1][2].
CAS Number
23674-86-4
UNSPSC
12352211
Hazard Statement
H315, H319, H335, H361
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Difluprednate.html
Concentration
10mM
Purity
99.64
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C([C@]([C@]12C)(CC[C@@]1([H])[C@@](C[C@H](F)C3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C2)OC(CCC)=O)COC(C)=O
Molecular Formula
C27H34F2O7
Molecular Weight
508.55
Precautions
H315, H319, H335, H361
References & Citations
[1]Tajika T, et al. Metabolic profiles of difluprednate in rabbit ocular tissues after instillation of difluprednate ophthalmic emulsion. Xenobiotica. 2010 Aug;40 (8) :569-77.|[2]Tajika T, et al. Pharmacokinetic features of difluprednate ophthalmic emulsion in rabbits as determined by glucocorticoid receptor-binding bioassay. J Ocul Pharmacol Ther. 2011 Feb;27 (1) :29-34.|[3]Mithal, et al. Difluprednate: an overview. Delhi Journal of Ophthalmology 23.3 (2013) : 165-168.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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