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TC299423

CAT: 0804-HY-124110Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124110Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TC299423 is an orally active, brain-penetrant, selective and potent agonist for α6β2 and α4β2 nicotinic acetylcholine receptors (nAChRs) with anxiolytic and antinociceptive properties. TC299423 acts primarily through α6β2 nAChRs that are implicated in the anxiolytic effects of nicotine. TC299423 elicits reward-related behavior mediated through α6β2 nAChRs in hypersensitive α6L90’S mice. TC299423 elicits dopamine release and dose not suppress nicotine self-administration in rats. TC299423 is proming for rasearch of addiction and Parkinson’s disease[1][2].
CAS Number
1975146-56-5
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tc299423.html
Smiles
C1(/C2=CN=CN=C2)=C\CCNCCC1
Molecular Formula
C11H15N3
Molecular Weight
189.26
References & Citations
[1]Wall TR, et al. TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors. Front Pharmacol. 2017 Sep 26;8:641.|[2]Post M R. Agonist Binding Studies at Two Subtypes of the Nicotinic Acetylcholine Receptor Involved in Parkinson’s Disease and Addiction[D]. California Institute of Technology, 2016.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T70022-01TC299423

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