AmmTX3

• Description :

  AmmTX3 is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 is specific blocker of Kv4 channel. AmmTX3 inhibits the A-type K+ current (Ki: 131 nM) [1][2].

• UNSPSC :

  12352209

• Target :

  Potassium Channel

• Type :

  Peptides

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ammtx3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  [O=C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(NCC(N[C@H]1CCCNC(N)=N)=O)=O)=O)=O)NC2=O)C(N[C@@H](CCC(N)=O)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@H]3C(C)C)=O)NC1=O)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC4=CC=C(C=C4)O)C(N5[C@@H](CCC5)C(O)=O)=O)=O)NC3=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](C)C(NCC(N[C@H]2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)NC([C@H](CC6)NC6=O)=O]

• Molecular Formula :

  C158H262N50O48S6

• Molecular Weight :

  3822.47

• References & Citations :

  [1]Vacher H, et al. Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus. Eur J Biochem. 2002 Dec;269 (24) :6037-41. https://|[2]Maffie JK, et al. Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels. J Physiol. 2013 May 15;591 (10) :2419-27.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported