BAY-707

CAT: 0804-HY-112081-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112081-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY-707, a chemical probe, is a substrate-competitive, highly potent and selective inhibitor of MTH1 (NUDT1) with an IC50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy[1].
CAS Number
[2109805-96-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay-707.html
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCC)C(N1)=CC2=C1N=CC=C2N3CCOC[C@@H]3C
Molecular Formula
C15H20N4O2
Molecular Weight
288.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Ellermann M, et al. Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.ACS Chem Biol. 2017 Aug 18;12 (8) :1986-1992.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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