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GC7 Sulfate

CAT: 0804-HY-108314A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108314A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
CAS Number
150417-90-6
UNSPSC
12352211
Hazard Statement
H314
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GC7_Sulfate.html
Concentration
10mM
Purity
98.0
Solubility
H2O : 3 mg/mL (ultrasonic; warming)
Smiles
NC(NCCCCCCCN)=N.O=S(O)(O)=O
Molecular Formula
C8H22N4O4S
Molecular Weight
270.35
Precautions
H314
References & Citations
[1]Bandino A, et al. Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients. Cell Oncol (Dordr) . 2014 Dec;37 (6) :387-98.|[2]Lou B, et al. N1-guanyl-1,7-diaminoheptane (GC7) enhances the therapeutic efficacy of doxorubicin by inhibiting activation of eukaryotic translation initiation factor 5A2 (eIF5A2) and preventing the epithelial-mesenchymal transition in hepatocellular carcinoma cells. Exp Cell Res. 2013 Oct 15;319 (17) :2708-17.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

GC7 Sulfate
CAS Number150417-90-6
PubChem CID131842088
IUPAC Name2-(7-aminoheptyl)guanidine;sulfuric acid
Molecular FormulaC8H22N4O4S
Molecular Weight270.35
Topological Polar Surface Area173
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count17
Formal Charge0
Complexity200
SMILES
C(CCCN)CCCN=C(N)N.OS(=O)(=O)O
InChI
InChI=1S/C8H20N4.H2O4S/c9-6-4-2-1-3-5-7-12-8(10)11;1-5(2,3)4/h1-7,9H2,(H4,10,11,12);(H2,1,2,3,4)
InChIKey
MDDOWYFCKAAANU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of GC7 Sulfate
CAS: 150417-90-6
CID: 131842088
Formula: C8H22N4O4S
MW: 270.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight270.35
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass270.13617637
Monoisotopic Mass270.13617637
Topological Polar Surface Area173 Ų
Heavy Atom Count17
Formal Charge0
Complexity200
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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