Phenformin (hydrochloride) (Standard)

Phenformin (hydrochloride) (Standard)

• CAS Number: 834-28-6
• UNSPSC Description: Phenformin (hydrochloride) (Standard) is the analytical standard of Phenformin (hydrochloride). This product is intended for research and analytical applications. Phenformin hydrochloride is an anti-diabetic agent from the biguanide class, can activate AMPK activity.
• Target Antigen: AMPK; Autophagy
• Type: Reference Standards
• Related Pathways: Autophagy;Epigenetics;PI3K/Akt/mTOR
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/phenformin-hydrochloride-standard.html
• Smiles: NC(NC(NCCC1=CC=CC=C1)=N)=N.Cl
• Molecular Weight: 241.72
• References & Citations: [1]Sakamoto K, et al. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Am J Physiol Endocrinol Metab.?2004 Aug;287(2):E310-7.|[2]Zhang L, et al. Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H457-66.|[3]Moreira AL, et al. Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp Med. 1993 Jun 1;177(6):1675-80.|[4]Woollhead AM, et al. Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells. J Physiol. 2005 Aug 1;566(Pt 3):781-92. Epub 2005|[5]Dilman VM, et al. Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats. Arch Geschwulstforsch. 1978;48(1):1-8.
• Shipping Conditions: Room temperature