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NS3861

CAT: 0804-HY-110121A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110121A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and binds with high affinity to heteromeric α3β4 nAChR. The binding Ki values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively[1].
CAS Number
216853-59-7
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ns3861.html
Concentration
10mM
Purity
99.78
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
BrC1=C(SC=C1)C2=CC(CCC3C2)N3C
Molecular Formula
C12H14BrNS
Molecular Weight
284.22
References & Citations
[1]Kasper Harpsøe, et al. Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J Biol Chem. 2013 Jan 25;288 (4) :2559-70.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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