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Human IDH1 Protein

CAT: 0013-GTR18877649-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18877649-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The IDH enzymes catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (α-KG), producing nicotinamide adenine dinucleotide phosphate (NADPH) in the process via the citric acid cycle. Eukaryotic cells express two distinct classes of IDHs that utilize either NAD or NADP as their cofactors and serve diverse biological functions. NAD-dependent IDH is localized to the mitochondrial matrix and is well known for its central role for energy production in the Krebs cycle. NADP-dependent IDHs are primarily located either in mitochondria or cytoplasm . Each NADP-dependent isozyme is a homodimer. Mutations of Arg132 of human IDH1 result in a reduced ability of the enzyme to convert isocitrate to alpha ‐ketoglutarate, but the enzyme acquires the ability to generate 2-hydroxyglutarate (2HG) from alpha‐ketoglutarate,2-HG is elevated in several tumor types, including a subset of AMLs.
Product Name Alternative
IDH1, PICD, IDP
UniProt
O75874
Expression Region
Met 1 - Leu 414
Reactivity
Human
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human IDH1, His Tag (orb864211) is expressed from E. coli cells. It contains AA Met 1 - Leu 414 (Accession # O75874-1) .
Field of Research
Metabolism Research
Purity
95%
Form
Liquid
Molecular Weight
48.5 kDa
Storage Conditions
-70°C
Notes
For research use only.
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 48.5 kDa. The protein migrates as 45-50 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) .
NCBI Accession Number
O75874
Preservative
50 mM Tris, 150 mM NaCl, 1 mM TCEP, pH7.5

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