Sodium 4-aminosalicylate (dihydrate) (Standard)

Sodium 4-aminosalicylate (dihydrate) (Standard)

• CAS Number: 6018-19-5
• UNSPSC Description: Sodium 4-aminosalicylate (dihydrate) (Standard) is the analytical standard of Sodium 4-aminosalicylate (dihydrate). This product is intended for research and analytical applications. Sodium 4-aminosalicylate (Sodium para-Aminosalicylic acid) dihydrate is para-aminosalicylic acid (PAS), a dihydrofolate reductase (DHFR) inhibitor and antituberculous agent. PAS is incorporated into the folate pathway via dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate the hydroxydihydrofolate antimetabolite, which in turn inhibits DHFR enzyme activity[1][2][3].
• Target Antigen: Antibiotic; Bacterial
• Type: Reference Standards
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sodium-4-aminosalicylate-dihydrate-standard.html
• Smiles: O=C(O[Na])C1=C(O)C=C(N)C=C1.O.O
• Molecular Weight: 211.15
• References & Citations: [1]Zheng J, et al. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. J Biol Chem. 2013 Aug 9;288(32):23447-56.|[2]Abdu-Allah HHM, et al. Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem. 2020 Jan;94:103378.
• Shipping Conditions: Room temperature