Sodium citrate (dihydrate)

• UNSPSC Description:

  Sodium citrate dehydrate (Trisodium citrate dihydrate) is a natural product with oral activity that can be found in citrus fruits. Sodium citrate dehydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dehydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dehydrate can be prepared as a cosolvent or buffer[1][2][3].

• Target Antigen:

  Apoptosis; Bacterial; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Apoptosis;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Sodium_citrate_dihydrate.html

• Purity:

  98.0

• Solubility:

  10 mM in DMSO|H2O : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(CC(C(O[Na])=O)(O)CC(O[Na])=O)O[Na].O.O

• Molecular Weight:

  294.10

• References & Citations:

  [1]Lu P, et al. Rosmarinic Acid and Sodium Citrate Have a Synergistic Bacteriostatic Effect against Vibrio Species by Inhibiting Iron Uptake. Int J Mol Sci. 2021 Dec 1;22(23):13010.|[2]Guo X,et al. 3-Bromopyruvate and sodium citrate induce apoptosis in human gastric cancer cell line MGC-803 by inhibiting glycolysis and promoting mitochondria-regulated apoptosis pathway. Biochem Biophys Res Commun. 2016 Jun 17;475(1):37-43.|[3]Ou Y, et al. Sodium Citrate Inhibits Endoplasmic Reticulum Stress in Rats with Adenine-Induced Chronic Renal Failure. Am J Nephrol. 2015;42(1):14-21.Regen Biomater. 2024 Aug 22:11:rbae098.|Adv Sci (Weinh). 2024 Oct 30:e2408707.|Carbohydr Polym. 2024 Dec 15:346:122645.|Exp Cell Res. 2020 Aug 1;393(1):112054.|Heliyon. 2024 Jan 17.|J Ethnopharmacol. 2024 Jan 12:117759.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|J Nanobiotechnology. 2023 Oct 19;21(1):383.|Nat Commun. 2024 Sep 10;15(1):7923.|Nature. 2023 Jun;618(7964):374-382.|Phytother Res. 2024 Mar 25.|SSRN. 2024 Mar 20.|Theranostics. 2020 Jul 25;10(21):9477-9494. |Bioengineered. 2021 Dec;12(2):11610-11621.|Biol Trace Elem Res. 2023 May 8.|Biomed Pharmacother. 2023 Aug 18;166:115333.|Drug Des Devel Ther. 2024 Feb 1:18:259-275.|Front Immunol. 2024 Oct 1:15:1397727.|Front Mol Biosci. 22 July 2022.|Int J Biol Sci. 2024 Aug 6;20(11):4222-4237.|Oxid Med Cell Longev. 2022 Apr 25;2022:3846217.|Research Square Preprint. 2021 Jul.|Food Chem. 2022: 134807.|Nature. 2024 Dec 18.|New J Chem. 03 Aug 2022.|Insect Biochem Mol Biol. 2023 May 12;103958.|J Virol. 2023 Jun 22;e0051223.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  6132-04-3