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Calindol (hydrochloride)

CAT: 0804-HY-122819-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122819-01Size:5 mg
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Description
Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM[1].
CAS Number
729610-18-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CaSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/calindol-hydrochloride.html
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H](NCC1=CC2=CC=CC=C2N1)C3=C4C=CC=CC4=CC=C3.Cl
Molecular Formula
C21H21ClN2
Molecular Weight
336.86
Precautions
H302, H315, H319, H335
References & Citations
[1]Lionel Kiefer, et al. Design and synthesis of calindol derivatives as potent and selective calcium sensing receptor agonists. Bioorg Med Chem. 2016 Feb 15;24 (4) :554-69. |[2]Albane Kessler, et al. N2-benzyl-N1- (1- (1-naphthyl) ethyl) -3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor. Bioorg Med Chem Lett. 2004 Jun 21;14 (12) :3345-9.|[3]Harry Z E Greenberg, et al. The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca2+ channels. Eur J Pharmacol. 2016 Nov 15;791:659-668.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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