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L-748328

CAT: 0804-HY-118944Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118944Size:1 Each
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Description
L-748328 is a potent and selective human β3-adrenergic receptor antagonist. L-748328 has a Ki of 3.7 nM against human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. In addition, L-748328 inhibits the lipolytic response induced by the β3-AR agonist L-742791 in isolated non-human primate adipocytes[1].
CAS Number
244192-93-6
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/l-748328.html
Smiles
O=S(C1=CC=CC(OC[C@H](CNCCC2=CC=C(C=C2)NS(=O)(C3=CC=CC=C3)=O)O)=C1)(N)=O
Molecular Formula
C23H27N3O6S2
Molecular Weight
505.61
References & Citations
[1]Candelore M R, et al. Potent and selective human β3-adrenergic receptor antagonists[J]. Journal of Pharmacology and Experimental Therapeutics, 1999, 290 (2) : 649-655.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β adrenergic receptor

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