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8-Epidiosbulbin E acetate

CAT: 0804-HY-N7047-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7047-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
8-Epidiosbulbin E acetate, a furanoid, is abundant in Dioscorea bulbifera L.. 8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. 8-Epidiosbulbin E acetate induces liver injury in mice[1][2].
CAS Number
91095-48-6
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Bacterial
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/8-epidiosbulbin-e-acetate.html
Purity
98.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(O[C@@H]1[C@@]([C@@](C(O2)=O)([H])C[C@@]2([H])C3)([H])[C@]3([H])[C@](C)(C[C@@H](C4=COC=C4)O5)[C@@](C5=O)([H])C1)=O
Molecular Formula
C21H24O7
Molecular Weight
388.41
Precautions
H315, H319
References & Citations
[1]Shriram V, et al. A potential plasmid-curing agent, 8-epidiosbulbin E acetate, from Dioscorea bulbifera L. against multidrug-resistant bacteria. Int J Antimicrob Agents. 2008 Nov;32 (5) :405-10.|[2]Lin D, et al. Role of Metabolic Activation in 8-Epidiosbulbin E Acetate-Induced Liver Injury: Mechanism of Action of the Hepatotoxic Furanoid. Chem Res Toxicol. 2016 Mar 21;29 (3) :359-66.|[3]Shi W, et al. Metabolomic-transcriptomic landscape of 8-epidiosbulbin E acetate -a major diterpenoid lactone from Dioscorea bulbifera tuber induces hepatotoxicity. Food Chem Toxicol. 2020 Jan;135:110887.|[4]Lin D, et al. In vitro and in vivo studies of the metabolic activation of 8-epidiosbulbin E acetate[J]. Chemical Research in Toxicology, 2015, 28 (9) : 1737-1746.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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