α-Tocopherol (phosphate)

• Description:

  α-Tocopherol phosphate is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate exhibits angiogenesis-promoting activity[1][2].

• Product Name Alternative:

  Alpha-Tocopherol phosphate; TocP; vitamin E phosphate

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  Apoptosis; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_alpha_-tocopherol-phosphate.html

• Purity:

  98.0

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

• Smiles:

  CC1=C (O[C@@] (CCC[C@H] (C) CCC[C@H] (C) CCCC (C) C) (C) CC2) C2=C (C) C (OP (O) (O) =O) =C1C

• Molecular Formula:

  C29H51O5P

• Molecular Weight:

  510.69

• Precautions:

  H315, H319

• References & Citations:

  [1]Wu Z, Zheng X, Meng L, et al. α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions. J Vasc Surg. 2018;67 (4) :1263-1273|[2]Saleh MM, et al. The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro. Sci Rep. 2021 Nov 17;11 (1) :22400.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 4

• CAS Number:

  38976-17-9