α-Tocopherol (phosphate)

• Description :

  α-Tocopherol phosphate is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate exhibits angiogenesis-promoting activity[1][2].

• Product Name Alternative :

  Alpha-Tocopherol phosphate; TocP; vitamin E phosphate

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  Apoptosis; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/_alpha_-tocopherol-phosphate.html

• Purity :

  98.0

• Solubility :

  DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

• Smiles :

  CC1=C(O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CC2)C2=C(C)C(OP(O)(O)=O)=C1C

• Molecular Formula :

  C29H51O5P

• Molecular Weight :

  510.69

• Precautions :

  H315, H319

• References & Citations :

  [1]Wu Z, Zheng X, Meng L, et al. α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions. J Vasc Surg. 2018;67 (4) :1263-1273|[2]Saleh MM, et al. The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro. Sci Rep. 2021 Nov 17;11 (1) :22400.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 4

• CAS Number :

  [38976-17-9]