β-Tocopherol-d3

• Description :

  β-Tocopherol-d3 is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol[1][2][3].

• CAS Number :

  [936230-75-0]

• UNSPSC :

  12352005

• Target :

  Isotope-Labeled Compounds; Tyrosinase

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=C2C(CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)O2)=C(C([2H])([2H])[2H])C(O)=C1

• Molecular Formula :

  C28H45D3O2

• Molecular Weight :

  419.70

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Azzi A, et, al. d-alpha-tocopherol control of cell proliferation. Mol Aspects Med. 1993; 14 (3) : 265-71.|[3]Tasinato A, et, al. d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proc Natl Acad Sci U S A. 1995 Dec 19; 92 (26) : 12190-4.|[4]Kamei Y, et, al. Comparison of the inhibitory effects of vitamin E analogues on melanogenesis in mouse B16 melanoma cells. Cytotechnology. 2009 Apr; 59 (3) : 183-90.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported