Spiramide

CAT: 0804-HY-100971-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100971-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Spiramide (AMI-193) is a potent and selective antagonist of 5-HT2 and dopamine D2 receptor, with Kis of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT2 versus 5-HT1C (Ki=4300 nM) receptors. Spiramide exhibits antipsychotic activity[1][2][3].
CAS Number
[510-74-7]
Product Name Alternative
AMI-193
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/spiramide.html
Concentration
10mM
Purity
99.23
Solubility
DMSO : 20 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NCN(C2=CC=CC=C2)C13CCN(CCCOC4=CC=C(F)C=C4)CC3
Molecular Formula
C22H26FN3O2
Molecular Weight
383.46
References & Citations
[1]Ismaiel AM, et, al. Antagonism of 1- (2,5-dimethoxy-4-methylphenyl) -2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist. J Med Chem. 1993 Aug 20;36 (17) :2519-25.|[2]Czoty PW, et, al. Behavioral effects of AMI-193, a 5-HT (2A) - and dopamine D (2) -receptor antagonist, in the squirrel monkey. Pharmacol Biochem Behav. 2000 Oct;67 (2) :257-64.|[3]Kjellberg B, et, al. Partial restoration by a neuroleptic (spiramide) of items of grooming behaviour suppressed by amphetamine. Arch Int Pharmacodyn Ther. 1974 Jul;210 (1) :61-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; D1 Receptor; D2 Receptor; mLAG-3; α-1 microglobulin

Related Products

CatalogName
HY-N1210Spiramine A
HY-N1208Spiradine F

Alternative Products

CatalogName
461054Spiramide

Popular Products