HECT E3-IN-1

HECT E3-IN-1

• CAS Number: 1810058-52-6
• UNSPSC Description: HECT E3-IN-1 (compound 3) is a HECT E3 ligase inhibitor. HECT E3-IN-1 (compound 3) disrupts Ub binding to the noncovalent Ub-binding site of Nedd4-1[1].
• Target Antigen: E1/E2/E3 Enzyme
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/hect-e3-in-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC1=C(C(NC/C=C/C(OC)=O)=O)C2=CC(OC)=CC=C2N1C3CCCC3
• Molecular Weight: 370.44
• References & Citations: [1]Stefan G Kathman, et al. A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J Am Chem Soc. 2015 Oct 7;137(39):12442-5.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported