(R)-Methanandamide

• UNSPSC Description:

  (R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a Ki of 20 nM. (R)-Methanandamide also activates vanilloid (TRPV1) receptors[1][2].

• Target Antigen:

  Cannabinoid Receptor; TRP Channel

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/r-methanandamide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(N[C@H](C)CO)=O

• Molecular Weight:

  361.56

• References & Citations:

  [1]V Abadji, et al. (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem. 1994 Jun 10;37(12):1889-93.|[2]M J M Fischer, et al. Cannabinoid and vanilloid effects of R(+)-methanandamide in the hemisected meningeal preparation. Cephalalgia. 2007 May;27(5):422-8.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  157182-49-5