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(R) -Methanandamide

CAT: 0804-HY-101389-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101389-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a Ki of 20 nM. (R) -Methanandamide also activates vanilloid (TRPV1) receptors[1][2].
CAS Number
157182-49-5
Product Name Alternative
AM-356
UNSPSC
12352211
Hazard Statement
H225, H315, H319, H335
Target
Cannabinoid Receptor; TRP Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r-methanandamide.html
Concentration
10mM
Purity
99.61
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(N[C@H](C)CO)=O
Molecular Formula
C23H39NO2
Molecular Weight
361.56
Precautions
H225, H315, H319, H335
References & Citations
[1]V Abadji, et al. (R) -methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem. 1994 Jun 10;37 (12) :1889-93.|[2]M J M Fischer, et al. Cannabinoid and vanilloid effects of R (+) -methanandamide in the hemisected meningeal preparation. Cephalalgia. 2007 May;27 (5) :422-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB1; TRPV1

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