Terpendole I

• Description:

  Terpendole I, a fungal indoloditerpene, is a ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor (IC50=145 µM) [1].

• UNSPSC:

  12352005

• Target:

  Acyltransferase; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/terpendole-i.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]12[C@@]([H])(CC[C@]3([C@]45[C@]([H])(CC[C@@]32C)O[C@@H]([C@H]([C@H]4O5)O)C(O)(C)C)O)CC6=C1NC7=C6C=CC=C7

• Molecular Formula:

  C27H35NO5

• Molecular Weight:

  453.57

• References & Citations:

  [1]Tomoda H, et al. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components. J Antibiot (Tokyo) . 1995;48 (8) :793-804.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Microbial Metabolite

• CAS Number:

  [167612-17-1]