Gentamicin C1a

• Description :

  Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H311, H331, H341

• Target :

  Antibiotic; Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/gentamicin-c1a.html

• Purity :

  98.0

• Solubility :

  H2O : 250 mg/mL (ultrasonic)

• Smiles :

  O[C@@H]([C@@H]([C@H](C[C@H]1N)N)O[C@H]2O[C@@H](CC[C@H]2N)CN)[C@H]1O[C@@H]3[C@@H]([C@H]([C@@](O)(CO3)C)NC)O

• Molecular Formula :

  C19H39N5O7

• Molecular Weight :

  449.54

• Precautions :

  H301, H311, H331, H341

• References & Citations :

  [1]Li D, et al. Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. Microbiol Res. 2013 Jun 12;168 (5) :263-7. |[2]Ishikawa M, et al. Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use. Sci Rep. 2019 Feb 20;9 (1) :2410. |[3]Isoherranen N, et al. Pharmacokinetics of gentamicin C (1), C (1a), and C (2) in beagles after a single intravenous dose. Antimicrob Agents Chemother. 2000 Jun;44 (6) :1443-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [26098-04-4]