C1A

• Description :

  C1A is a class I/II HDACs and sirtuin inhibitor with an IC50 of 479 nM for HDAC6. C1A induces sustained acetylation of HDAC6 substrates, α-tubulin and HSP90. C1A shows srtong anticancer effcts, and induces apoptosis in cancer cells[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; HDAC; Sirtuin

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/c1a.html

• Smiles :

  ClCCN(C1=CC=C(C=C1)S(NC2=CC=C(C=C2)/C=C(C)/C=C/C(NO)=O)(=O)=O)CCCl

• Molecular Formula :

  C22H25Cl2N3O4S

• Molecular Weight :

  498.42

• References & Citations :

  [1]M Kaliszczak, et al. A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth. Br J Cancer. 2013 Feb 5;108 (2) :342-50.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC1; HDAC10; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9; SIRT3

• CAS Number :

  [1021463-02-4]