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C1A

CAT: 0804-HY-124946Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124946Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C1A is a class I/II HDACs and sirtuin inhibitor with an IC50 of 479 nM for HDAC6. C1A induces sustained acetylation of HDAC6 substrates, α-tubulin and HSP90. C1A shows srtong anticancer effcts, and induces apoptosis in cancer cells[1].
CAS Number
1021463-02-4
UNSPSC
12352005
Target
Apoptosis; HDAC; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c1a.html
Smiles
ClCCN(C1=CC=C(C=C1)S(NC2=CC=C(C=C2)/C=C(C)/C=C/C(NO)=O)(=O)=O)CCCl
Molecular Formula
C22H25Cl2N3O4S
Molecular Weight
498.42
References & Citations
[1]M Kaliszczak, et al. A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth. Br J Cancer. 2013 Feb 5;108 (2) :342-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9; SIRT3

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