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DB1113

CAT: 0804-HY-148061-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148061-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity[1].
CAS Number
2769753-53-7
UNSPSC
12352005
Target
Bcr-Abl; CDK; Cyclin G-associated Kinase (GAK) ; Ferroptosis; LIM Kinase (LIMK) ; MAP4K; MAPKAPK2 (MK2) ; PROTACs; Salt-inducible Kinase (SIK) ; ULK
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; PROTAC; Protein Tyrosine Kinase/RTK
Applications
COVID-19-anti-virus
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db1113.html
Purity
99.86
Solubility
DMSO : 60 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC(NC(C3=CC(C(F)(F)F)=CC=C3)=O)=CC=C2C)CC4=CN=C(NC5=CN=C(N6CCN(CC6)CCCCC(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C9=C(N=CS9)C)C=C8)C)=O)=O)=O)C=C5)N=C4N1C
Molecular Formula
C59H68F3N13O6S
Molecular Weight
1144.31
References & Citations
[1]Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK11; CDK4; LIMK1; MAP4K1/HPK1; MAP4K2/GCK; MAP4K3/GLK; MAP4K5/KHS1; SIK2; SIK3; ULK1

Alternative Products

CatalogName
BA3424-1DB1113

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