α-Amyrin

• UNSPSC Description:

  α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission[1][2][3].

• Target Antigen:

  ERK; GSK-3

• Type:

  Natural Products

• Related Pathways:

  MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/α-amyrin.html

• Purity:

  99.94

• Solubility:

  10 mM in DMSO|Methanol : 1 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@H]([C@@H]4C)C)C)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC2)C)C

• Molecular Weight:

  426.72

• References & Citations:

  [1]Giacoman-Martínez A, et al. α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts. Can J Physiol Pharmacol. 2021 Sep;99(9):935-942.|[2]Prabhakar P, et al. α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats. Appl Physiol Nutr Metab. 2017 Jan;42(1):23-32.|[3]Park SJ, et al. Amyrin attenuates scopolamine-induced cognitive impairment in mice. Biol Pharm Bull. 2014;37(7):1207-13.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  638-95-9