Nerandomilast

CAT: 0804-HY-153192-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-153192-01Size:1 mg
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Description
Nerandomilast (BI 1015550) is an orally active inhibitor of PDE4B with an IC50 value of 7.2 nM. Nerandomilast has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD) [1][2].
CAS Number
[1423719-30-5]
Product Name Alternative
BI 1015550
UNSPSC
12352005
Hazard Statement
H302, H361, H372
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Neurological Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nerandomilast.html
Purity
99.93
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=[S@]1C2=C(CC1)N=C(N3CCC(CC3)C4=NC=C(C=N4)Cl)N=C2NC5(CO)CCC5
Molecular Formula
C20H25ClN6O2S
Molecular Weight
448.97
Precautions
H302, H361, H372
References & Citations
[1]Pouzet P A, et al. Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma. United States. US9150586.|[2]Herrmann FE, et al. BI 1015550 is a PDE4B Inhibitor and a Clinical Drug Candidate for the Oral Treatment of Idiopathic Pulmonary Fibrosis. Front Pharmacol. 2022 Apr 20;13:838449.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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