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Gemilukast

CAT: 0804-HY-16780-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16780-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gemilukast is an orally active and potent dual cysteinyl leukotriene 1 and 2 receptors (CysLT1 and CysLT2) antagonist, with IC50s of 1.7, 25 nM for human CysLT1 and CysLT2, respectively. Gemilukast is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
1232861-58-3
Product Name Alternative
ONO-6950
UNSPSC
12352005
Target
Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Gemilukast.html
Purity
99.49
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)CCCN1C(C)=C(CCCC(O)=O)C2=C1C(C#CC3=CC=C(OCCCCC4=CC=CC(F)=C4C)C=C3)=CC=C2F
Molecular Formula
C36H37F2NO5
Molecular Weight
601.68
References & Citations
[1]Itadani S, et al. Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma. J Med Chem. 2015 Aug 13;58 (15) :6093-113.|[2]Yonetomi Y, et al. Effects of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptors antagonist, in a guinea pig model of asthma. Eur J Pharmacol. 2015 Oct 15;765:242-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LTC4/CysLT2; LTD4/CysLT1

Alternative Products

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BA5446-5Gemilukast
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A21021-25Gemilukast 25mg
A21021-5Gemilukast 5mg
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A21021-100Gemilukast 100mg
A21021-10Gemilukast 10mg
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