Products for Research Use Only

TNF Antibody

CAT: 0013-GTR18795226Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18795226Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anti-TNFRSF7/CD27 Antibody (Varlilumab) is a humanized agonistic monoclonal antibody targeting CD27 (TNFRSF7) . This product specifically binds to the CD27 receptor on T cells, mimicking the costimulatory signal of the CD70 ligand and triggering the activation of the NF-kappaB signaling pathway. This action enhances the activation, proliferation, and cytokine secretion (such as IFN-gamma) of antigen-specific T cells. In preclinical models, the antibody induces potent anti-tumor immune responses; in clinical studies, combination with PD-1 inhibitors modulates the immune microenvironment and increases circulating chemokine levels.
Target
TNF
Clonality
Monoclonal
Conjugation
Unconjugated
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.