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Others Antibody

CAT: 0013-GTR18795210-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18795210-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anti-PCSK9 Antibody is a humanized monoclonal antibody targeting Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) . PCSK9 is a serine protease primarily secreted by the liver that binds to the Low-Density Lipoprotein Receptor (LDLR) on the hepatocyte surface, promoting its internalization and lysosomal degradation, thereby preventing LDLR recycling to the cell surface. This reduces the liver's ability to clear LDL-cholesterol (LDL-C) from the blood. Anti-PCSK9 Antibody specifically binds to PCSK9, blocking its interaction with LDLR and inhibiting PCSK9-mediated LDLR degradation. This action increases the density of LDLR on hepatocytes, enhances LDL-C clearance, and significantly lowers serum cholesterol levels. It is widely used in research on hypercholesterolemia and atherosclerotic cardiovascular diseases.
Target
Others
Clonality
Monoclonal
Conjugation
Unconjugated
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.

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