Products for Research Use Only

TNF Antibody

CAT: 0013-GTR18795172Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18795172Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anti-TNFSF2/TNFa Antibody (hMAK195) is a humanized monoclonal antibody targeting tumor necrosis factor alpha (TNF-α/TNFSF2), serving as a biosimilar to Afelimomab. TNF-α is a critical pro-inflammatory cytokine primarily produced by macrophages and T cells, playing a central role in inflammatory responses, apoptosis, and immune regulation. hMAK195 specifically binds to both soluble and membrane-bound TNF-α, blocking their interaction with cell surface receptors (TNFR1 and TNFR2) and thereby inhibiting the activation of downstream NF-κB and MAPK signaling pathways. This antibody effectively neutralizes TNF-α-induced cytotoxicity and inflammatory cascades, making it a valuable tool for researching sepsis, rheumatoid arthritis, and other inflammatory diseases.
Target
TNF
Clonality
Monoclonal
Conjugation
Unconjugated
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.