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Beta-Secretase Antibody

CAT: 0013-GTR18795251Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18795251Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anti-BACE1 Antibody is a humanized monoclonal antibody targeting beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) . BACE1 is a transmembrane aspartic protease and the rate-limiting enzyme for the generation of Aβ peptides in Alzheimer's disease (AD) . This antibody functions by specifically binding to the extracellular domain of BACE1, neutralizing its enzymatic activity or inducing receptor internalization to block the beta-site cleavage of amyloid precursor protein (APP) . This process effectively reduces the production of toxic Aβ40/42 and inhibits the formation and deposition of amyloid plaques, making it a pivotal tool for researching the pathogenesis and immunotherapeutic strategies of neurodegenerative diseases.
Target
Beta-Secretase
Clonality
Monoclonal
Conjugation
Unconjugated
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.

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