DBCO-Maleimide

• UNSPSC Description:

  DBCO-Maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• Target Antigen:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dbco-maleimide.html

• Purity:

  99.83

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(NCCC(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)=O)CCN4C(C=CC4=O)=O

• Molecular Weight:

  427.45

• References & Citations:

  [1]Modified antibody and radioactive metal-labelled antibody. WO2019203191A1.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  1395786-30-7