Clenbuterol

CAT: 0804-HY-B1615Size: 1 EachDry Ice: NoHazardous: No

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Description

Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM[1]. Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS) -induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator[2].

CAS Number

37148-27-9

Product Name Alternative

NAB-365

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/clenbuterol.html

Purity

99.00

Solubility

10 mM in DMSO

Smiles

CC(C)(NCC(C1=CC(Cl)=C(C(Cl)=C1)N)O)C

Molecular Formula

C12H18Cl2N2O

Molecular Weight

277.19

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Gilad Barnea, et al. The genetic design of signaling cascades to record receptor activation. Proc Natl Acad Sci U S A. 2008 Jan 8;105 (1) :64-9.|[2]Olga Witkowska-Piłaszewicz, et al. The Effect of the Clenbuterol-β2-Adrenergic Receptor Agonist on the Peripheral Blood Mononuclear Cells Proliferation, Phenotype, Functions, and Reactive Oxygen Species Production in Race Horses In Vitro. Cells. 2021 Apr 17;10 (4) :936.|[3]Min Chen, et al. Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling. Int J Biol Sci. 2017 Oct 17;13 (10) :1341-1350.|[4]Nikolaos Mellios, et al. β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A. 2014 Jul 8;111 (27) :9947-52.|[5]A F Lehner, et al. Clenbuterol in the horse: confirmation and quantitation of serum clenbuterol by LC-MS-MS after oral and intratracheal administration. J Anal Toxicol. May-Jun 2001;25 (4) :280-7.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

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