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UNC9994

CAT: 0804-HY-117829-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117829-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC9994, an analog of Aripiprazole, is a functionally selective β-arrestin-biased dopamine D2 receptor (D2R) agonist with EC50 i-regulated cAMP production. Antipsychotic Activity[1].
CAS Number
1354030-51-5
Product Name Alternative
3M-852A
UNSPSC
12352005
Target
5-HT Receptor; Arrestin; Dopamine Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/unc9994.html
Purity
98.06
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC(C2CCN(CC2)CCCOC3=CC4=C(C=C3)SC=N4)=C1Cl
Molecular Formula
C21H22Cl2N2OS
Molecular Weight
421.38
References & Citations
[1]Allen JA, et al. Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A. 2011;108 (45) :18488-18493.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor; D3 Receptor; D4 Receptor; H1 Receptor; Histamine Receptor; mLAG-3; α-1 microglobulin

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