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D-Ala-D-Ala

CAT: 0804-HY-W015450-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W015450-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-Ala-D-Ala is a bacterial endogenous metabolite. D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase[1][2][3].
CAS Number
923-16-0
Product Name Alternative
D-Alanyl-D-alanine; H-D-Ala-D-Ala-OH
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/d-ala-d-ala.html
Purity
98.0
Solubility
DMSO : 2 mg/mL (ultrasonic; adjust pH to 5 with HCl) |H2O : 100 mg/mL (ultrasonic)
Smiles
C[C@H](C(O)=O)NC([C@@H](C)N)=O
Molecular Formula
C6H12N2O3
Molecular Weight
160.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Kitamura Y, et al. Structure of D-alanine-D-alanine ligase from Thermus thermophilus HB8: cumulative conformational change and enzyme-ligand interactions. Acta Crystallogr D Biol Crystallogr. 2009 Oct;65 (Pt 10) :1098-106.|[2]Tytgat I, et al. DD-ligases as a potential target for antibiotics: past, present and future. Curr Med Chem. 2009;16 (20) :2566-80.|[3]Trivedi RR, et al. Mechanical Genomic Studies Reveal the Role of d-Alanine Metabolism in Pseudomonas aeruginosa Cell Stiffness. mBio. 2018 Sep 11;9 (5) :e01340-18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Microbial Metabolite

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