CA77.1

CAT: 0804-HY-134923-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-134923-01Size:5 mg
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Description
CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's disease research[1].
CAS Number
[2412270-22-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ca77-1.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3N=C2)C=C1)=O
Molecular Formula
C16H12ClN3O
Molecular Weight
297.74
Precautions
H302, H315, H319
References & Citations
[1]Mathieu Bourdenx, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.Cell. 2021 May 13;184 (10) :2696-2714.e25.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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