CA77.1

• UNSPSC Description:

  CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in?lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's?disease research[1].

• Target Antigen:

  Autophagy

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ca77-1.html

• Smiles:

  CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3N=C2)C=C1)=O

• Molecular Weight:

  297.74

• References & Citations:

  [1]Mathieu Bourdenx, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.Cell. 2021 May 13;184(10):2696-2714.e25.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2412270-22-3