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CTNNB1 Antibody (N-term)

CAT: 0013-GTR18785345-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18785345-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to CTNNB1. Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2.
Product Name Alternative
Anti CTNNB1 antibody, anti CTNNB antibody, anti Catenin beta-1 antibody, anti Catenin beta-1 antibody, anti Beta-catenin antibody
UniProt
P35222
Reactivity
Human
Immunogen
Synthetic Peptide
Target
CTNNB1
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cancer Biology, Cardiovascular Research, Neuroscience, Signal Transduction
Dilution
WB - 1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Molecular Weight
85497
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Notes
For research use only.
Prediction Reactivity
Mouse, Other, Rat, Zebrafish
Tested Applications
WB
NCBI Accession Number
NP_001091680.1, NP_001091679.1, NP_001895.1
Host or Source
Rabbit
Isotype
Rabbit IgG

UniProtKB · P35222

Catenin beta-1

CTNB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35222
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CTNNB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K1L7, Q8NEW9, Q8NI94, Q9H391
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationGlycoproteinPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

Activator

Biological process

Cell adhesionHost-virus interactionNeurogenesisTranscriptionTranscription regulationWnt signaling pathway

Cellular component

Cell junctionCell membraneCell projectionCytoplasmCytoskeletonMembraneNucleusSynapse

Coding sequence diversity

Chromosomal rearrangement

Disease

Disease variantIntellectual disability

Domain

Repeat

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