IT1t (dihydrochloride)

• UNSPSC Description:

  IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM.

• Target Antigen:

  CXCR; HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;GPCR/G Protein;Immunology/Inflammation

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology; Endocrinology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/IT1t_dihydrochloride.html

• Purity:

  99.77

• Solubility:

  DMSO : ≥ 30 mg/mL|H2O : 50 mg/mL (ultrasonic)

• Smiles:

  CC1(C)CN2C(CS/C(NC3CCCCC3)=N\C4CCCCC4)=CSC2=N1.[H]Cl.[H]Cl

• Molecular Weight:

  479.57

• References & Citations:

  [1]Van Hout A, et al. Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors. PLoS One. 2017 Apr 14;12(4):e0176057.|[2]Wu B, et al. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science. 2010 Nov 19;330(6007):1066-71.|[3]Tulotta C, et al. Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1timpairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model. Dis Model Mech. 2016 Feb;9(2):141-53.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  1092776-63-0