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Dexmedetomidine

CAT: 0804-HY-12719-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12719-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dexmedetomidine ((+) -Medetomidine) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3].
CAS Number
113775-47-6
Product Name Alternative
(+) -Medetomidine; (S) -Medetomidine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/dexmedetomidine.html
Purity
99.93
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C[C@H](C1=CN=CN1)C2=CC=CC(C)=C2C
Molecular Formula
C13H16N2
Molecular Weight
200.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Virtanen R, et, al. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988 May 20;150 (1-2) :9-14.|[2]Gertler R, et, al. Dexmedetomidine: a novel sedative-analgesic agent. Proc (Bayl Univ Med Cent) . 2001 Jan;14 (1) :13-21.|[3]Sajid B, et, al. A comparison of oral dexmedetomidine and oral midazolam as premedicants in children. J Anaesthesiol Clin Pharmacol. Jan-Mar 2019;35 (1) :36-40.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α adrenergic receptor
Citation 01
Am J Chin Med. 2025;53 (2) :501-522.|Biomed Pharmacother. 2023 Dec 31:169:115915.|Brain Res Bull. 2025 Aug 24:230:111523.|Brain Res. 2025 Jan 30:149482.|Cancer Metab. 2025 Jun 23;13 (1) :33.|Cardiovasc Drugs Ther. 2025 Feb;39 (1) :33-42.|Chem Biol Drug Des. 2025 Apr;105 (4) :e70100.|Drug Des Devel Ther. 2024 Apr 9:18:1103-1114.|Front Biosci (Landmark Ed) . 2025 Feb 20, 30 (2), 27159.|Front Biosci (Landmark Ed) . 2025 Feb 20;30 (2) :27159.|Histol Histopathol. 2025 Mar 28:18914.|Hum Exp Toxicol. 2025 Jan-Dec:44:9603271251336467.|J Neuropathol Exp Neurol. 2022 Sep 19;81 (10) :836-849.|J Toxicol Sci. 2023;48 (3) :139-148.|Kaohsiung J Med Sci. 2025 May 15:e70045.|Metab Brain Dis. 2025 Nov 5;40 (8) :306.|Mol Cell Toxicol. 2023 Jun 2.|Neurochem Res. 2025 Apr 9;50 (2) :138.|Sci Rep. 2025 Sep 29;15 (1) :33699.|University of Colorado Denver. 2024.|Eur J Neurosci. 2021 Dec;54 (11) :7775-7789.|Hum Exp Toxicol. 2021 Dec;40 (12) :2145-2155.|Nat Commun. 2023 Jul 7;14 (1) :4011.|Pharmacology. 2022;107 (1-2) :14-27.

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