Products for Research Use Only
RegisterLogin

Quinolinic acid-d3

CAT: 0804-HY-100807S-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-100807S-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Quinolinic acid-d3 is the deuterium labeled Quinolinic acid. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.
CAS Number
138946-42-6
UNSPSC
12352005
Target
Apoptosis; Endogenous Metabolite; iGluR; Isotope-Labeled Compounds; NO Synthase; Reactive Oxygen Species (ROS)
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
99.90
Solubility
DMSO : 33.33mg/mL (ultrasonic) |H2O : 3.33mg/mL (ultrasonic)
Smiles
[2H]C1=C([2H])C([2H])=C(C(O)=O)C(C(O)=O)=N1
Molecular Formula
C7H2D3NO4
Molecular Weight
170.14
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Jang S, et al. Neuroprotective effects of (-)-epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition. Brain Res. 2010 Feb 8;1313:25-33.|[3]Heyes MP, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 ( Pt 5):1249-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
NMDA Receptor

Related Products

CatalogName
HY-100807-01Quinolinic acid
HY-100807R-01Quinolinic acid (Standard)
HY-100807S1Quinolinic acid-13C7
HY-W654331-01Quinolinic acid-13C3, 15N
HY-100807S2Quinolinic acid-13C4,15N
HY-W004260S2-01Arachidic acid-d3
HY-N2041S3-01Myristic acid-d3
HY-B1053S-01Iotalamic acid-d3
HY-14781S3Levomefolic acid-d3
HY-113121SVanillylmandelic acid-d3

Alternative Products

CatalogName
Q0100-01Quinolinic Acid
IS-I-0100RQuinolinic Acid ELISA
A20575-500Quinolinic acid 500mg
A20575-10000Quinolinic acid 10g
abx165808-01Quinolinic Acid (BSA)
A20575-1000Quinolinic acid 1g
abx165809-01Quinolinic Acid (OVA)
OOCD00371-200UGQuinolinic Acid (OVA - Conjugated)
OKCD02284-96WQuinolinic Acid ELISA Kit
IMS-IS002Quinolinic Acid monoclonal antibody

Popular Products