Quinolinic acid

CAT: 0804-HY-100807-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100807-01Size:500 mg
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Description
Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis[1][2][3][4][5][6][7][8].
CAS Number
[89-00-9]
UNSPSC
12352005
Hazard Statement
H319, H335
Target
Apoptosis; Endogenous Metabolite; iGluR; NO Synthase; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Quinolinic_acid.html
Purity
99.88
Solubility
DMSO : 33.33 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=CC=C1C(O)=O)O
Molecular Formula
C7H5NO4
Molecular Weight
167.12
Precautions
H319, H335
References & Citations
[1]Heyes MP, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 (Pt 5) :1249-73.|[2]Jang S, et al. Neuroprotective effects of (-) -epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition. Brain Res. 2010 Feb 8;1313:25-33.|[3]Sugisawa E, et al. Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia. Cell Rep. 2022 Mar 8;38 (10) :110462.|[4]Lisak RP, et al. Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damage. Exp Neurol. 2015 Nov;273:161-7.|[5]Lapin IP. Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice. J Neural Transm. 1978;42 (1) :37-43.|[6]Goel F, et al. Protective effects of diacerein against quinolinic acid-induced Huntington's disease-like symptoms in adult zebrafish by targeting GSK-3β signalling. Naunyn Schmiedebergs Arch Pharmacol. 2025 Aug;398 (8) :10799-10821.|[7]Bains M, et al. Anti-inflammatory effects of ellagic acid and vanillic acid against quinolinic acid-induced rat model of Huntington's disease by targeting IKK-NF-κB pathway. Eur J Pharmacol. 2022 Nov 5;934:175316.|[8]Martínez-Gopar PE, et al. Mast cells and histamine are involved in the neuronal damage observed in a quinolinic acid-induced model of Huntington's disease. J Neurochem. 2022 Jan;160 (2) :256-270.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite; NMDA Receptor

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