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AM404

CAT: 0804-HY-101388-01Size: 5 mg (126.4 mM x 100 μL in Ethanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-101388-01Size:5 mg (126.4 mM x 100 μL in Ethanol)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC50 values in the low micromolar range[1]. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 μM) . Neuroprotective Effect[2].
CAS Number
183718-77-6
UNSPSC
12352005
Hazard Statement
H225, H319
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/am404.html
Concentration
126.4 mM * 200 μL in Ethanol
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(NC1=CC=C(O)C=C1)=O
Molecular Formula
C26H37NO2
Molecular Weight
395.58
Precautions
H225, H319
References & Citations
[1] A Giuffrida, et al. Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology. J Pharmacol Exp Ther. 2001 Jul;298 (1) :7-14.|[2]Kent-Olov Jonsson, et al. AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch Toxicol. 2003 Apr;77 (4) :201-7.|[3]Marco Bortolato, et al. Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology. 2006 Dec;31 (12) :2652-9.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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